World's Best Scientists 2026 revealed!
Charles ffrench-Constant

Charles ffrench-Constant

D-Index & Metrics

Biology and Biochemistry

D-Index
97
Citations
29634
World Ranking
1772
National Ranking
116

Research.com Recognitions

  • 2018 - Fellow of the Royal Society of Edinburgh
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Charles ffrench-Constant is a researcher affiliated with the University of Edinburgh in the United Kingdom. Their work predominantly spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Neuroscience, with notable contributions across subfields including Molecular Biology, Developmental Neuroscience, Cellular and Molecular Neuroscience, Neurology, and Genetics.

The researcher focuses on several main topics of study, which include:

  • Neurogenesis and neuroplasticity mechanisms
  • Neuroinflammation and Neurodegeneration Mechanisms
  • RNA regulation and disease
  • RNA Research and Splicing
  • Connexins and lens biology
  • Multiple Sclerosis Research Studies
  • Nerve injury and regeneration

Among the frequent co-authors in their publications are Peter Connick, Steffen Mayerl, Siddharthan Chandran, David A. Lyons, and Marie E. Bechler.

They have published extensively in various venues, with notable frequency in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Developmental Cell
  • BIO-PROTOCOL
  • Nature Reviews Neurology
  • The Lancet Neurology

Representative recent papers by Charles ffrench-Constant include:

  • "Hypomyelinating leukodystrophies - unravelling myelin biology," 2020, published in Nature Reviews Neurology
  • "Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study," 2021, published in The Lancet Neurology
  • "iPSC-derived myelinoids to study myelin biology of humans," 2021, published in Developmental Cell
  • "Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis," 2022, published in Brain Behavior and Immunity
  • "PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS," 2020, published in EMBO Molecular Medicine

They have been recognized through awards including election as a Fellow of the Royal Society of Edinburgh in 2018 and as a Fellow of The Academy of Medical Sciences, United Kingdom.

Best Publications

  • Remyelination in the CNS: from biology to therapy

    Robin J. M. Franklin;Charles ffrench-Constant

  • M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

    Veronique E. Miron;Amanda Boyd;Jing Wei Zhao;Tracy J. Yuen;Tracy J. Yuen

  • Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat.

    C Ffrench-Constant;L Van de Water;H F Dvorak;R O Hynes

  • Altered human oligodendrocyte heterogeneity in multiple sclerosis

    Sarah Jäkel;Eneritz Agirre;Ana Mendanha Falcão;David van Bruggen

  • Retinoid X receptor gamma signaling accelerates CNS remyelination

    Jeffrey K Huang;Andrew A Jarjour;Brahim Nait Oumesmar;Christophe Kerninon

  • Regenerating CNS myelin — from mechanisms to experimental medicines

    Robin J M Franklin;Charles Ffrench-Constant

  • Evidence for specific cognitive deficits in preclinical Huntington's disease.

    Andrew David Lawrence;J. R. Hodges;Anne Elizabeth Rosser;A. Kershaw

  • Proliferating bipotential glial progenitor cells in adult rat optic nerve

    Charles ffrench-Constant;Martin C. Raff

  • The Chemokine Receptor CXCR2 Controls Positioning of Oligodendrocyte Precursors in Developing Spinal Cord by Arresting Their Migration

    Hui Hsin Tsai;Emma Frost;Vivien To;Shenandoah Robinson

  • Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

    Alexander Raven;Wei-Yu Lu;Tak Yung Man;Sofia Ferreira-Gonzalez

  • Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

    Ana Mendanha Falcão;David van Bruggen;Sueli Marques;Mandy Meijer

  • Generation of an environmental niche for neural stem cell development by the extracellular matrix molecule tenascin C.

    Emmanuel Garcion;Aida Halilagic;Andreas Faissner;Charles ffrench-Constant

  • CNS Myelin Sheath Lengths Are an Intrinsic Property of Oligodendrocytes

    Marie E. Bechler;Lauren Byrne;Charles ffrench-Constant

  • Individual Oligodendrocytes Have Only a Few Hours in which to Generate New Myelin Sheaths In Vivo

    Tim Czopka;Charles ffrench-Constant;David A. Lyons

  • Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.

    Iben Lundgaard;Aryna Luzhynskaya;John H. Stockley;Zhen Wang

  • β1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance

    Lia S. Campos;Dino P. Leone;Joao B. Relvas;Cord Brakebusch

  • Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype.

    Lorenza Ciani;Anjila Patel;Nicholas Denby Allen;Charles ffrench-Constant

  • Neuroprotection and repair in multiple sclerosis

    Robin J. M. Franklin;Charles ffrench-Constant;Julia M. Edgar;Kenneth J. Smith

  • Alternative splicing of fibronectin is temporally and spatially regulated in the chicken embryo

    C. Ffrench-Constant;R.O. Hynes

  • A developmental analysis of oligodendroglial integrins in primary cells: changes in alpha v-associated beta subunits during differentiation.

    R. Milner;C. Ffrench-Constant

Frequent Co-Authors

Robin J.M. Franklin
Robin J.M. Franklin University of Cambridge
Andreas Faissner
Andreas Faissner Ruhr University Bochum
James W. Fawcett
James W. Fawcett University of Cambridge
Richard Milner
Richard Milner San Diego Biomedical Research Institute
Chao Zhao
Chao Zhao University of Cambridge
Wia Baron
Wia Baron University Medical Center Groningen
Diana Baralle
Diana Baralle University of Southampton
Siddharthan Chandran
Siddharthan Chandran University of Edinburgh
Mark P. Mattson
Mark P. Mattson Johns Hopkins University
David A. Lyons
David A. Lyons University of Edinburgh

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